MDM2 and lung cancer: Several studies have reported that tumors, including lung cancer, are strongly associated with inflammation, and upregulation of the ribosome biogenesis rate might be involved in tumor transformation in tissues affected by chronic inflammation, upregulation of rRNA transcription results in increased MDM2-mediated degradation of P53 proteasome, which reduces P53 expression and promotes tumorigenesis (Donati et al., 2011).