Interestingly, Shank3 mutant macaques demonstrate reduced pulling force, while Shank3 KO mice exhibit impaired wire-hanging time, endurance, and motor coordination, analogous to the hypotonia observed in PMS patients (Zhou et al., 2019; Lutz et al., 2020; Bauer et al., 2023). This evidence concerns the gene SHANK3 and premenstrual tension.