SHANK3 and Phelan-McDermid syndrome: SHANK3 is located on chromosome 22q13.3, whose mutation leads to a haploinsufficiency of the SHANK3 protein and causes a rare genetic developmental disorder, called Phelan-McDermid syndrome (Durand et al., 2007; Delahaye et al., 2009; Sarasua et al., 2011; Phelan and McDermid, 2012).