Current research suggests that in addition to being involved in the regeneration of neuronal axons and regulating the cell cycle, BEX1 is also involved in the proliferation and invasion (Vilar et al., 2006; Khazaei et al., 2010; Doi et al., 2020; Lee et al., 2021) showed that BEX1 and BEX4 can improve the tumor formation and radio resistance of glioblastoma multiforme cells. This evidence concerns the gene BEX4 and neoplasm.