In cancer, it enhances tumor cell growth and metastasis through epithelial to mesenchymal transition (Fernando et al., 2011), formation of neutrophil extracellular traps (Alfaro et al., 2016), angiogenesis and infiltration of inflammatory cells that suppress antitumor CD3+/CD8+ T cell functions (David et al., 2016). The gene discussed is CD8A; the disease is neoplasm.