PRKN and amyotrophic lateral sclerosis: Therefore, we speculate that the OMM proteins are further ubiquitinated by activated Parkin (Narendra and Youle, 2011) and recruit mitophagy receptors, including the amyotrophic lateral sclerosis (ALS)-associated protein optineurin (OPTN), NDP52, and TAX1BP1 (Moore and Holzbaur, 2016; Ryan and Tumbarello, 2018), to a similar extent in control or CPZ-treated cells.