Like rodents, bears, and hedgehogs (Hoo-Paris et al., 1978; Melnyk et al., 1983; Moreau-Hamsany et al., 1988; Tokuyama et al., 1991; Rigano et al., 2017), dwarf lemurs can show signatures of lean-season insulin resistance, including elevated fasting insulin and HOMA-IR values, lower fasting glucose, and reduced glucose tolerance compared the fattening and/or active seasons. Here, INS is linked to Insulin resistance.