(134) The pathophysiology of hypertension due to VEGF inhibitors include; (i) reduced nitric oxide (NO) production by endothelial cells which can trigger immune cell infiltration and vascular inflammation causing damage to the endothelium (135); (ii) increased endothelin-1 production by endothelial cells (136); and (iii) capillary rarefaction (137). The gene discussed is VEGFA; the disease is hypertensive disorder.