In other instances, metabolic reprograming involves the synergistic interaction of SREBF2 with other transcription factors such as early growth response element 1 (EGR1) (Gokey et al., 2011) and the nuclear receptor RAR-related receptor gamma (RORγ) to promote cholesterol biosynthesis, particularly in cancer (Cai et al., 2019). The gene discussed is EGR1; the disease is cancer.