NOTCH1 and acute lymphoblastic leukemia: Likewise, the JURKAT cell line is also important in advancing our understanding of T-ALL pathogenesis as these cells carry several genetic anomalies, including the rearrangement of the T-cell receptor (TCR) and activation of the NOTCH1 signaling pathway, which are common characteristics of T-ALL pathogenesis (Abraham and Weiss, 2004; Gioia et al., 2018).