PTEN and neoplasm: The Reactome pathway enrichment analysis with a padj > 0.05 as a threshold displayed the association of the DEGs with various vital cell cycle-related pathways, including mitotic G1-G1/S phases, G1/S transition, M/G1 transition, and tumor suppressor pathways, including PTEN regulation and signaling by the TGF-beta receptor complex (Figure 3D).