Chemokines can either directly act on SREBP2 to activate the pathway, as evident in the tropism of breast cancer to the lungs, where CCL2/CCL7 produced from the lung fibroblast stimulates the synthesis of cholesterol by activating SREBF2 in lung-colonizing breast cancer cells to fuel the metastatic niche (Han et al., 2022). Here, SREBF2 is linked to breast cancer.