CNR1 and diabetic neuropathy: CB1R, CB2R, and TRPV1 channels are upregulated in the spinal cord and the DRGs of different models of neuropathic pain (Lim et al., 2003; Hsieh et al., 2011; Vuckovic et al., 2018), such as diabetic neuropathy (Hong and Wiley, 2005; Ikeda et al., 2013).