In particular, the upregulation of the genes MSMO1, IDI1, LSS, and HMGCR suggested enhanced synthesis of cholesterol, and the upregulation of FASN suggested an increased synthesis of fatty acids that may in turn induce phospholipidosis (Sawada et al., 2005; Antherieu et al., 2011). Here, FASN is linked to lysosomal storage disease.