Gerokonstantis et al. (2020) synthesized 2-pyrrolidinone and pyrrolidine derivatives and evaluated the enzyme inhibition activities of autotaxin (ATX) isolated from melanoma cells, which are responsible for various pathological inflammations such as fibrosis, cancer, liver toxicity, and thrombosis due to hydrolysis of lysophosphatidylcholine (LPC). Here, ENPP2 is linked to cancer.