DMF anti-proliferative effect against tumoral cells is mainly linked to its regulation of the nuclear translocation of NF-kB, of the Nrf2 pathway, of extracellular signal-regulated kinase 1 and 2 (ERK1/2), and p38 mitogen-activated protein kinases (MAPKs), while its suppression of tumor metastasis is connected to inhibition of matrix metalloproteinases (MMPs) and very late antigens (VLAs) (Saidu et al., 2019; Takeda et al., 2020). Here, MAPK3 is linked to neoplasm.