S100B and injury: The study observed serum S100β levels and Kanofsky’s performance status (KPS) score, indexes of brain injury and the ability of patients to carry out daily tasks, respectively; the Authors remark no significant change in serum S100β level, but a higher mean KPS score, suggesting that DMF’s neuroprotective action might not be due to the prevention of BBB integrity disruption, but to other mechanisms (Milad et al., 2022).