GCLC and colitis: DMF also restored Nrf2 protein level and NQO1 and H O -1 expression; Li et al. (2020) further investigated in the DSS-induced colitis model the DMF’s effect on the gut antioxidant system, with specific focus on glutamate-cysteine ligase catalytic subunit (GCLC), glutathione peroxidase (GPX) and COX-2.