SOD1 and Sepsis: A strong preventing antioxidant activity of DMF has indeed been observed in a rat model of organ sepsis; 15 mg/kg of DMF administered immediately and 12 h after sepsis induction resulted in reduced neutrophil infiltration in peripheral organs (i.e., liver, lung), and in the prevention of nitrite/nitrate increase and oxidative damage to lipids (measured through the production of MDA equivalents) and proteins (measured through carbonyl content), and restored superoxide dismutase (SOD) and catalase activity (Giustina et al., 2017).