Results: Seven significant (p < 6.81 × 10−5) plasma protein-SCLC pairs were identified by MR analysis, including ACP5 (OR = 0.76, 95% CI: 0.67–0.86), CPB2 (OR = 0.90, 95% CI: 0.86–0.95), GSTM3 (OR = 0.45, 95% CI: 0.33–0.63), SHMT1 (OR = 0.74, 95% CI: 0.64–0.86), CTSB (OR = 0.79, 95% CI: 0.71–0.88), NTNG1 (OR = 0.81, 95% CI: 0.74–0.90) and FAM171B (OR = 1.40, 95% CI: 1.21–1.62). The gene discussed is SHMT1; the disease is small cell lung carcinoma.