Some studies have suggested that the metabolic disorders in patients are related to neurotransmitters such as serotonin 5-HT2A/2C receptors and histamine H1 receptors (Kim et al., 2007; Esen-Danacı et al., 2008); others have suggested that it may be the result of clozapine affecting the production or the secretion mechanism of adipocytokines such as adiponectin, leptin, and resistin in the body (Yuen et al., 2021). Here, LEP is linked to Other metabolic disease.