Since C-type natriuretic peptide is predominantly expressed in by endothelial cells and released during sepsis (Koch et al., 2011) and septic encephalopathy from endothelial cells, its N-terminal propeptide (NT-proCNP) may serve as an indicator of injury to the cerebrovascular endothelium (Ehler et al., 2020). Here, NPPC is linked to Sepsis.