The amino-terminal propeptide of the C-type natriuretic peptide (NT-proCNP) was compared as a biomarker of septic encephalopathy with neuron-specific enolase (NSE) and S100B protein in 12 patients diagnosed septic encephalopathy and 9 non-septic control patients without encephalopathy. The gene discussed is S100B; the disease is Encephalopathy.