MAPT and early-onset autosomal dominant Alzheimer disease: Alzheimer’s disease (AD) is characterized by an abnormal aggregation and deposition of amyloid-β peptides of different lengths into extracellular plaques and of hyperphosphorylated Tau protein (p-Tau) into intracellular neurofibrillary tangles, followed by progressive cognitive and functional decline (Andrews et al., 2023).