Changes in the mRNAexpression of genes involved in the intrinsic process of apoptosis(Bcl-2, Bax, CASPASE-3, and CASPASE-9) in HepG2 cancer cells were examined by quantitative polymerasechain reaction (qPCR) using SYBR Green Master Mix to determine theeffects of CCM CD-decorated chitosan NP. The gene discussed is BAX; the disease is cancer.