TNF and metabolic dysfunction-associated steatohepatitis: Of interest, under NASH progression, there is a shift in the inflammatory state from the production of the anti-inflammatory cytokines to the production of the proinflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), which play an important role in the liver regeneration process [10, 11].