Children:- total and specific IgE higher than adults (p < 0.001)- lower median tryptase than adults (p = 0.009)Increased VIT-SR risk if first reaction was grade 4 compared to grade 3 (p = 0.016); grade 1–2 field reactions did not show any VIT-SRIncreased VIT-SR risk in children allergic to honeybee compared to wasp allergy (p = 0.058).No difference adults/children who experienced VIT-SR with respect to asthma, atopy, severity previous reaction, skin tests or sIgE. Here, IGHE is linked to asthma.