PLA2G4A and Cerebral ischemia: In fact, it has been shown that cPLA2α is a crucial component in the pathway of stroke injury (Bonventre, 1996) and that the inhibition of c-PLA2 attenuates focal ischemic brain damage in mice with cerebral ischemia-reperfusion injury (Bonventre, 1996; Liu et al., 2017).