ACSL4 and Alzheimer disease: Moreover, cPLA2 activation is located closer to the ER-mitochondria-overproducing MAMs in AD, which activates another enzyme that produces the incorporation of PUFAs on PLs, such as ACSL4 (Acyl-CoA synthetase long-chain family member 4), and an increase in arachidonic derivatives (Kuwata and Hara, 2019).