PLA2G4A and Alzheimer disease: In addition, silencing of BACE1 achieved the regulation of plasmalogens such as LPE and ePE, which were recovered from the AD environment in the hippocampus of a 3xTgAD mouse model, mainly its FA composition modifying 18:0 for 18:1 and 20:4 for 22:6, in the context of proinflammatory reversion reducing cPLA2 and COX-2 (Villamil-Ortiz et al., 2016).