MAPT and Alzheimer disease: Recurrent HSV-1 infection induces oxidative damage (Protto et al., 2020) that is linked to AD-related pathophysiology, including dysregulation of calcium homeostasis, Aβ accumulation, tau hyperphosphorylation, synaptic dysfunction, neuroinflammation and neurodegeneration (Zhao and Zhao, 2013; Tönnies and Trushina, 2017).