Recently, a growing body of evidence has suggested that epigenetic modifications, particularly DNA methylation, may play a crucial role in the development and progression of PD and could play a role in pathogenesis including α-synuclein misfolding and aggregation, mitochondrial dysfunction, impaired protein clearance, neuroinflammation, and oxidative stress (Pieper et al., 2008; Masliah et al., 2013; Coupland et al., 2014; Su et al., 2015; Eryilmaz et al., 2017; Jankovic and Tan, 2020; Kia et al., 2021). This evidence concerns the gene SNCA and Parkinson disease.