APOE and peripheral nervous system disorder: Moreover, ApoE alleles have been reported to influence the progression and incidence of a variety of peripheral nervous system diseases (Bedlack et al., 2000), and some studies (Petersen et al., 2016; Skoog et al., 2016), but not all (Alfred et al., 2014; Maltais et al., 2019; Kuo et al., 2020), have suggested that ApoE status is associated with age-related changes in motor function (e.g., grip strength).