HSP90B2P and Parkinson disease: It is the opinion of the researchers that: (1) exercise in the heat may influence HSP expression more positively versus exercise in a thermoneutral environment; (2) changes in (1–2°C), and upper limits of (≤ 39°C), core temperature should be closely monitored during exercise or passive heat treatments in those with PD; (3) passive heat application before, during, or after aerobic exercise could have an additive effect on treating PD symptomology, with careful attention paid to introducing these interventions in research design.