Interestingly, PARP1 activation is known to dysregulate SIRT1 activity via NAD+ depletion during skeletal muscle fatigue, aging, and cerebral ischemia, and deletion of PARP1 results in increased SIRT1 activity, higher mitochondrial content, and increased energy expenditure (72–76). The gene discussed is SIRT1; the disease is Cerebral ischemia.