Therefore, in osteomyelitis, it is likely that S. aureus survives in the phagosome by interfering with the expression of LC3-modified protein production, and it is necessary to investigate the mechanisms by which S. aureus affects LC3 expression in osteomyelitis; it may be a new strategy to effectively block these pathways and restore the function of the phagosome to kill pathogens (31). The gene discussed is MAP1LC3A; the disease is osteomyelitis.