IL22 and chronic rhinosinusitis with nasal polyps: They performed DDA and DIA proteomic analysis on nasal secretions from CRSwNP, CRSsNP, and normal control, respectively, and identified 2020 proteins and the expression of interleukin (IL)-7, IL-9, IL-17A and IL-22 and neutrophil-mediated immune responses were significantly increased in CRSwNP compared to control (14).