highly selective Syk inhibitor, improves MPO-ANCA glomerulonephritis in a pre-clinical ANCA vasculitis model in Wistar Kyoto rats; delays renal progression in NZB/NZW mice in lupus nephritis model and anti-GBM glomerulonephritis in Sprague-Dawley and WKY rats. This evidence concerns the gene SYK and glomerulonephritis.