GZMB and neoplasm: Given the importance of CD8 T cells in mediating anti-tumor immune responses to monotherapy with other HDACi (9, 10) and previous reports of specific HDACs and HDACi in regulating the cytotoxic gene programs of CD8 T cells during development (48), we determined whether OKI-179 changed expression of the cytotoxic molecule granzyme B (GrzB) by CD8 T cells in patients.