The TME of gliomas is complex and heterogeneous, consisting of various components, including astrocytes, pericytes, endothelial cells, GSCs, blood vessels, glioma-associated stromal cells, immune cells including myeloid-derived suppressor cells (MDSCs), glioma-associated microglia/macrophages (GAMs), CD4+ T cells, Tregs and NK cells, and extracellular matrix (ECM) (107–109) (Figure 1). Here, CD4 is linked to central nervous system cancer.