We propose the name NASA (neuroinflammation, autoinflammation, splenomegaly and anemia) for this new autoinflammatory disease, and emphasize that clinicians should consider each component of the acronym separately since treatment with IL-6 blockade so far has proven extremely efficacious for systemic autoinflammation and transfusion dependent anemia but has not had any impact on the neuroinflammation or massive splenomegaly. This evidence concerns the gene IL6 and anemia.