CXCR4 and neoplasm: On the other hand, the chemokine receptors present on the LEC surface are mainly involved in the processes of tumor-specific lymphangiogenesis and lymphatic metastasis, e.g. CXCR4 targeting CXCL12 present on both tumoral and stromal cells, CXCR2 with an affinity for CXCL5 in melanoma cells, and CXCL1 expressed by LECs in gastric cancer (87, 154, 155).