Notably, the overall signal patterns demonstrated that malignant cells with high KIF18B expression triggered more immunosuppressive pathways, such as the BAG, NOTCH, PTN, SAA, SEMA5/6, and WNT, suggesting that these molecular interactions were involved in the impaired anti-tumor immunity mediated by KIF18B (Figure 7C). The gene discussed is PTN; the disease is neoplasm.