Intrathecal synthesis of IgG according to Reiber (17) was less frequent in MOGAD than in MS patients (13.3% vs. 52.9%, p<0.001), whereas there was no significant difference in intrathecal synthesis of IgA (0.0% vs. 7.9%, p=0.233) and IgM (13.3% vs. 17.5%, p=0.794) (Table 4). The gene discussed is CD40LG; the disease is myeloid sarcoma.