MutSigCV identified the significantly mutated genes in the CRC cohort as follows: adenomatous polyposis coli (APC, 72%), SOX9 (17%), TP53 (77%), KRAS (61%), SMAD4 (19%), and FBWX7 (21%), which is similar to the results of previous studies (Suppl. The gene discussed is SMAD4; the disease is colorectal carcinoma.