Sporadic variants account for about 75% of all adult MTC, and mutations were identified not only in the RET gene, in which single and multiple point mutations as well as small deletions/deletions–insertions are described, but also other cancer-related genes, the alteration of which has been reported either alone or in association with the RET/RAS drivers (Minna et al., 2022). The gene discussed is RET; the disease is medullary thyroid gland carcinoma.