Additionally, a study showed that IL-17 could promote myocardial fibrosis via PKC β/Erk1/2/NF- κB signaling pathway (Liu et al., 2012), and the cAMP signaling pathway may play a critical role in idiopathic pulmonary fibrosis (Wang et al., 2021). This evidence concerns the gene MAPK3 and Myocardial fibrosis.