CASC8 and coronary artery disorder: Sun et al. (2020) proposed that PVT1 promotes vascular endothelial cell proliferation by inhibiting miR-190a-5p, contributing to chronic heart failure. Researchers found increased PVT1 expression in peripheral blood monocytes of CAD patients (Nowrouzi-Sohrabi et al., 2022). Lu et al. (2021) reported that CASC8, CASC11 and PVT1 genetic polymorphisms were associated with the Gensini score in CAD patients.