There are some molecular alterations that had never been reported in solid tumors before, including BRAF-PXK fusion, FLNC-BRAF fusion, BRAFN486_T491delinsS, PAX8C147R, PTEND252Rfs∗42, and TERTQ302R, as well as the EIF1AX c.338-2A>T splice site mutation and the KIAA1217-RET fusion in thyroid cancers. The gene discussed is PXK; the disease is thyroid cancer.