F13A1 and hyperinsulinemic hypoglycemia, familial, 4: The majority of blood factors (e.g., clotting factor VIII; coagulation factors VIIa, IX, Xa, IIa, thrombolytic reteplase) are produced in mammalian cells, except several examples of yeast platforms, such as clotting fibrin stabilizing factor XIIIa expressed in S. cerevisiae, which treats congenital factor XIIIa deficiency and is commercialized since 2012, as well as P. pastoris-synthesized clotting plasma kallikrein inhibitor and proteolytic recombinant plasmin approved in 2009 and 2012, respectively (Martínez et al., 2012; Korte, 2014; Walsh, 2018) (Table 1).