For example, activation of NF-κB/Bcl-2/Snail pathway increases chemotherapy resistance in NSCLC, and thus targeted drug delivery of this pathway would behave with good specificity and pharmacokinetic characteristics which could inhibit tumor cell proliferation (McCubrey et al., 2008; Chen et al., 2015; Asati et al., 2016). Here, NFKB1 is linked to neoplasm.