TNF and pancreatitis: Aruna et al. (44) suggested that rutin, a flavonoid glycoside, curtails pancreatitis through the downregulation of ASC–NLRP3, resulting in reduced caspase-1 activation and decreased IL-1β, IL-18, and tumor necrosis factor-α (TNF-α) pro-inflammatory cytokines expression and production in alcohol and cerulein-induced pancreatitis model.