In this work, we report the detection of the anti-SARS-CoV-2 IgM and IgG antibody response, by immunoassay approach, shortly after the beginning of the symptoms and up to 90 days afterward in patients with COVID-19 detected by RT-qPCR that did not require hospitalization (cases group), and clinically healthy individuals that were not suspected of being infected with COVID-19 and with a negative RT-qPCR for SARS-CoV-2, coming from Mexico City and the State of Mexico. The gene discussed is CD40LG; the disease is COVID-19.