To explore the potential roles of DNA demethylase in regulating IGF2BP3 promoter methylation levels in TNBC, we knocked down DNMT1/3A/3B and TET1/2/3 in MDA‐MB‐231 and HCC‐1806 cell lines using specific their siRNAs (Figure S1a–f). The gene discussed is IGF2BP3; the disease is hepatocellular carcinoma.