While ApoeKO and LDL‐receptor (LDLr) knockout models are commonly employed as atherosclerosis mouse models, Apoe3‐Leiden and PCSK9‐AAV models are valuable tools in atherosclerosis research37; the critical role of Rnd3 in ECs during atherosclerosis needs to be verified in human and other murine models. This evidence concerns the gene PCSK9 and atherosclerosis.