We previously demonstrated that many cancer-preventive or growth inhibitory food factors, such as vitamin D3, sulforaphane, flavone, butyrate, apigenin, all-trans retinoic acid, brassinin, indole-3-carbinol, sesamin, sesaminol, fucoxanthin, artepillin C, cryptolepine, vitamin K2, dehydrozingerone, perillyl alcohol, arctiin, L-canavanine, and resibufogenin, activated the functions of RB, suggesting the importance of RB for cancer prevention [11–32]. Here, RB1 is linked to cancer.