In cancer therapy, apigenin modulated PI3K/AKT/mTOR, MAPK/ERK, NF-κB, JAK/STAT, and Wnt/βcatenin signaling pathways PI3K / AKT / mTOR, MAPK / ERK, NF-κB, JAK / catenin, PI3K / AKT / mTOR, MAPK / ERK, NF-κB, JAK / STAT and Wnt / STAT and Wnt / catenin [46]. The gene discussed is MAPK1; the disease is cancer.