MDK and neoplasm: The univariate analyses demonstrated that ECOG performance status 1 or 2 (p < 0.001), T stage 4A/4B (p = 0.001), lymph node metastases (p = 0.005), AJCC tumor stage IVA/IVB (p < 0.001), positive LVI (p = 0.005, positive PNI (p < 0.001), positive extra-nodal extension (p < 0.001), the habitus of betel nuts chewing (p = 0.006), strong MDK (p = 0.001, Fig. 1B), and strong AT1R expression (p = 0.009, Fig. 1B) had poor shorter DFS (Table 3).