For the presence of diabetes mellitus pre- and post-intervention (yes/no; defined for participants with baseline fasting plasma glucose levels ≥ 126 mg/dL or hemoglobin-A1c levels ≥ 6.5% or if regularly treated with oral antihyperglycemic medications or exogenous insulin) and metabolic syndrome score (below/above 3), no significant differences or interactions were observed. The gene discussed is INS; the disease is diabetes mellitus.