For enterovirus group B, coxsackievirus B3 Nancy strain showed an oncolytic activity in xenografted mouse models of NSCLC, small cell lung cancer, KRAS-mutant lung adenocarcinomas, and colorectal carcinomas by specific receptors on cancer cell, including CAR, DAF, and heparan sulfates (HS). The gene discussed is CD55; the disease is small cell lung carcinoma.