CGAS and infection: The cGAS-STING pathway that recognizes DNA virus infection is canonical when it comes to STING activation.38 However, as an RNA virus, infection with CV-B5 stimulates cGAS and often activates RIG-I, which is another activator of STING.37,39 By knocking down or overexpress RIG-I in NCI-H460 cell, we also found similar phenomenon by contrast to control (Fig. 6c, d, Supplementary Fig 6c, d).