CAR is the main receptor of CV-B5, and DAF is a co-receptor that assists entry.23 CV-B5/F and CV-B5/JS417 did not induce cytolysis in normal lung cells, even at an MOI of 100, which ensured the security of CV-B5 used for the treatment of lung cancer (Fig. 2b, c). This evidence concerns the gene CD55 and lung cancer.