Although it shows tissue tropism for neurons, the receptor expression level in mature neurons becomes less susceptible to CV-B5 because of the decrease in CAR levels compared with immature neurons.43 Wang et al. also indicated that CAR is specifically expressed in various histological types of human lung cancers, but not in normal alveolar epithelial cells.44 In our study, compared to universal and homogeneous expression of DAF, CAR expression showed specificity in lung cancer cells with its oncolytic effect. The gene discussed is CD55; the disease is lung cancer.