We detected a decreased LRP1 level, reversely correlated with the increased LRPAP1 level followed by a viral infection or viral protease expression (e.g. 2Apro and 3CLpro), suggesting that the interaction between proteases and LRPAP1 interferes with LRP1 maturation, triggering a compensation for the continued production of LRPAP1. Here, LRPAP1 is linked to viral infectious disease.