It is reported that dysfunction or deficiency of LRPAP1 is associated with neurodegenerative diseases, including degenerative dementias (e.g., Alzheimer’s disease, Atherosclerosis, etc.)and myopia.17,18 Accumulating evidence indicates that these neurodegenerative diseases may be caused by attenuated innate immunity in response to chronic infections in the brain. This evidence concerns the gene LRPAP1 and neurodegenerative disease.