EV71 2Apro not only cleaves host proteins to enhance viral protein translation, but also interacts with many signaling proteins to regulate viral RNA process and translation.41,42 It was found that 2Apro also inhibits the processing body (P body) in host cells and sequester the component protein to promote viral RNA synthesis.43 Here, we show that both enterovirus 2Apro and SARS-CoV-2 3CLpro promoted the production and secretion of the host protein LRPAP1, a lipoprotein, to assist viral infection through targeting innate immune response. Here, LRPAP1 is linked to viral infectious disease.