Infections by many viruses (SARS-CoV-2, ZIKV, DENV, EV71, etc.)can cause severe neurological disorders and even death, such as aseptic meningitis, encephalitis, poliomyelitis-like paralysis, and mental disorders.28 To examine if LRPAP1 promoted virus infection in nerve cells in the brain, the effect of extracellular rLRPAP1 on membrane IFNAR1 was also confirmed ex vivo using mouse brains. Here, IFNAR1 is linked to viral infectious disease.